Novak Djokovic, the 2021 French Open top seed and world number one tennis player, advanced to the third round of the 2021 French Open men's singles with a 3-0 victory over Uruguayan Carlos Cuevas in the second round.

The 2021 French Open is the 16th time Djokovic has advanced to the third round of the French Open men's singles. Djokovic will next play Lithuanian Andriy Bielansky.